Gabapentinoids are a class of medications that include gabapentin and pregabalin, which are primarily used to treat neuropathic pain. These medications work by binding to specific receptors in the brain and spinal cord, ultimately reducing the transmission of pain signals. In recent years, there has been growing interest in the use of gabapentinoids for various off-label indications, such as anxiety, insomnia, and fibromyalgia. However, concerns have been raised about the potential for misuse and abuse of these medications, particularly in populations at risk for substance abuse. Research on gabapentinoids has focused on their efficacy and safety for various conditions, as well as their potential for abuse and dependence. There is also ongoing research on the pharmacology of these drugs and their mechanisms of action in the treatment of pain and other conditions.